首页> 外文OA文献 >Comparative genomic analysis of the Haloferax volcanii DS2 and Halobacterium salinarium GRB contig maps reveals extensive rearrangement.
【2h】

Comparative genomic analysis of the Haloferax volcanii DS2 and Halobacterium salinarium GRB contig maps reveals extensive rearrangement.

机译:对Haloferax volcanii DS2和Halobacterium salinarium GRB重叠群图谱的比较基因组分析揭示了广泛的重排。

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务,本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文,但由于OA文献来源多样且变更频繁,仍可能出现获取不到、文献不完整或与标题不符等情况,如果获取不到我们将提供退款服务。请知悉。

摘要

Anonymous probes from the genome of Halobacterium salinarium GRB and 12 gene probes were hybridized to the cosmid clones representing the chromosome and plasmids of Halobacterium salinarium GRB and Haloferax volcanii DS2. The order of and pairwise distances between 35 loci uniquely cross-hybridizing to both chromosomes were analyzed in a search for conservation. No conservation between the genomes could be detected at the 15-kbp resolution used in this study. We found distinct sets of low-copy-number repeated sequences in the chromosome and plasmids of Halobacterium salinarium GRB, indicating some degree of partitioning between these replicons. We propose alternative courses for the evolution of the haloarchaeal genome: (i) that the majority of genomic differences that exist between genera came about at the inception of this group or (ii) that the differences have accumulated over the lifetime of the lineage. The strengths and limitations of investigating these models through comparative genomic studies are discussed.
机译:将来自盐杆菌嗜盐杆菌GRB基因组的匿名探针和12个基因探针与粘粒克隆杂交,这些粘粒克隆代表了盐杆菌嗜盐杆菌GRB和Volofii volcanii DS2的染色体和质粒。为了保守性,分析了两个染色体唯一交叉杂交的35个基因座之间的顺序和成对距离。在这项研究中使用的15 kbp分辨率下,无法检测到基因组之间的保守性。我们在盐盐单胞菌GRB的染色体和质粒中发现了不同的低拷贝数重复序列集,表明这些复制子之间存在一定程度的分配。我们为盐生古细菌基因组的进化提出了另类的路线:(i)属之间存在的大多数基因组差异是在该群体开始时产生的;或(ii)差异在谱系的整个生命周期中已经积累。讨论了通过比较基因组研究研究这些模型的优势和局限性。

著录项

  • 作者

    St Jean, A; Charlebois, R L;

  • 作者单位
  • 年度 1996
  • 总页数
  • 原文格式 PDF
  • 正文语种 en
  • 中图分类

相似文献

  • 外文文献
  • 中文文献
代理获取

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号